Ontology highlight
ABSTRACT:
SUBMITTER: McDonnell SJ
PROVIDER: S-EPMC6718399 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
McDonnell Samantha J SJ Spiller David G DG White Michael R H MRH Prior Ian A IA Paraoan Luminita L
Cell death discovery 20190903
Specific molecular interactions that underpin the switch between ER stress-triggered autophagy-mediated cellular repair and cellular death by apoptosis are not characterized. This study reports the unexpected interaction elicited by ER stress between the plasma membrane (PM)-localized apoptosis effector PERP and the ER Ca<sup>2+</sup> pump SERCA2b. We show that the p53 effector PERP, which specifically induces apoptosis when expressed above a threshold level, has a heterogeneous distribution acr ...[more]