Ontology highlight
ABSTRACT:
SUBMITTER: Hu YB
PROVIDER: S-EPMC6718535 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Hu Yong-Bo YB Ren Ru-Jing RJ Zhang Yong-Fang YF Huang Yue Y Cui Hai-Lun HL Ma Chao C Qiu Wen-Ying WY Wang Hao H Cui Pei-Jing PJ Chen Hong-Zhuan HZ Wang Gang G
Aging cell 20190709 5
Rho-associated coiled-coil kinase 1 (ROCK1) is proposed to be implicated in Aβ suppression; however, the role for ROCK1 in amyloidogenic metabolism of amyloid precursor protein (APP) to produce Aβ was unknown. In the present study, we showed that ROCK1 kinase activity and its APP binding were enhanced in AD brain, resulting in increased β-secretase cleavage of APP. Furthermore, we firstly confirmed that APP served as a substrate for ROCK1 and its major phosphorylation site was located at Ser655. ...[more]