Ontology highlight
ABSTRACT:
SUBMITTER: Martini H
PROVIDER: S-EPMC6718537 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Martini Hélène H Iacovoni Jason S JS Maggiorani Damien D Dutaur Marianne M Marsal Dimitri J DJ Roncalli Jerome J Itier Romain R Dambrin Camille C Pizzinat Nathalie N Mialet-Perez Jeanne J Cussac Daniel D Parini Angelo A Lefevre Lise L Douin-Echinard Victorine V
Aging cell 20190729 5
Aging is a major risk factor in the development of chronic diseases, especially cardiovascular diseases. Age-related organ dysfunction is strongly associated with the accumulation of senescent cells. Cardiac mesenchymal stromal cells (cMSCs), deemed part of the microenvironment, modulate cardiac homeostasis through their vascular differentiation potential and paracrine activity. Transcriptomic analysis of cMSCs identified age-dependent biological pathways regulating immune responses and angiogen ...[more]