Ontology highlight
ABSTRACT:
SUBMITTER: Wongpalee SP
PROVIDER: S-EPMC6718625 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Wongpalee Somsakul Pop SP Liu Shiheng S Gallego-Bartolomé Javier J Leitner Alexander A Aebersold Ruedi R Liu Wanlu W Yen Linda L Nohales Maria A MA Kuo Peggy Hsuanyu PH Vashisht Ajay A AA Wohlschlegel James A JA Feng Suhua S Kay Steve A SA Zhou Z Hong ZH Jacobsen Steven E SE
Nature communications 20190902 1
Transcription by RNA polymerase V (Pol V) in plants is required for RNA-directed DNA methylation, leading to transcriptional gene silencing. Global chromatin association of Pol V requires components of the DDR complex DRD1, DMS3 and RDM1, but the assembly process of this complex and the underlying mechanism for Pol V recruitment remain unknown. Here we show that all DDR complex components co-localize with Pol V, and we report the cryoEM structures of two complexes associated with Pol V recruitme ...[more]