Ontology highlight
ABSTRACT:
SUBMITTER: Lv J
PROVIDER: S-EPMC6718666 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Lv Jiawei J Chen Yupei Y Zhou Guanqun G Qi Zhenyu Z Tan Kuan Rui Lloyd KRL Wang Haitao H Lin Li L Chen Foping F Zhang Lulu L Huang Xiaodan X Liu Ruiqi R Xu Sisi S Chen Yue Y Ma Jun J Chua Melvin L K MLK Sun Ying Y
Nature communications 20190902 1
Liquid biopsies have the utility for detecting minimal residual disease in several cancer types. Here, we investigate if liquid biopsy tracking on-treatment informs on tumour phenotypes by longitudinally quantifying circulating Epstein-barr virus (EBV) DNA copy number in 673 nasopharyngeal carcinoma patients undergoing radical induction chemotherapy (IC) and chemo-radiotherapy (CRT). We observe significant inter-patient heterogeneity in viral copy number clearance that is classifiable into eight ...[more]