Ontology highlight
ABSTRACT:
SUBMITTER: Adams B
PROVIDER: S-EPMC6718721 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Adams Büin B Nunes J Massimo JM Page Martin J MJ Roberts Timothy T Carr Jonathan J Nell Theo A TA Kell Douglas B DB Pretorius Etheresia E
Frontiers in aging neuroscience 20190827
Parkinson's disease (PD) is a well-known neurodegenerative disease with a strong association established with systemic inflammation. Recently, the role of the gingipain protease group from <i>Porphyromonas gingivalis</i> was implicated in Alzheimer's disease and here we present evidence, using a fluorescent antibody to detect gingipain R1 (RgpA), of its presence in a PD population. To further elucidate the action of this gingipain, as well as the action of the lipopolysaccharide (LPS) from <i>P. ...[more]