Clonal diversity predicts adverse outcome in chronic lymphocytic leukemia.
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ABSTRACT:
SUBMITTER: Leeksma AC
PROVIDER: S-EPMC6718955 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Clonal diversity predicts adverse outcome in chronic lymphocytic leukemia.
Leeksma Alexander C AC Taylor Justin J Wu Bian B Gardner Jeffrey R JR He Jie J Nahas Michelle M Gonen Mithat M Alemayehu Wendimagegn G WG Te Raa Doreen D Walther Tatjana T Hüllein Jennifer J Dietrich Sascha S Claus Rainer R de Boer Fransien F de Heer Koen K Dubois Julie J Dampmann Maria M Dürig Jan J van Oers Marinus H J MHJ Geisler Christian H CH Eldering Eric E Levine Ross L RL Miller Vincent V Mughal Tariq T Lamanna Nicole N Frattini Mark G MG Heaney Mark L ML Zelenetz Andrew A Zenz Thorsten T Abdel-Wahab Omar O Kater Arnon P AP
Leukemia 20180723 2
Genomic analyses of chronic lymphocytic leukemia (CLL) identified somatic mutations and associations of clonal diversity with adverse outcomes. Clonal evolution likely has therapeutic implications but its dynamic is less well studied. We studied clonal composition and prognostic value of seven recurrently mutated driver genes using targeted next-generation sequencing in 643 CLL patients and found higher frequencies of mutations in TP53 (35 vs. 12%, p < 0.001) and SF3B1 (20 vs. 11%, p < 0.05) and ...[more]
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