Ontology highlight
ABSTRACT:
SUBMITTER: Bertero A
PROVIDER: S-EPMC6719452 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Bertero Alessandro A Fields Paul A PA Smith Alec S T AST Leonard Andrea A Beussman Kevin K Sniadecki Nathan J NJ Kim Deok-Ho DH Tse Hung-Fat HF Pabon Lil L Shendure Jay J Noble William S WS Murry Charles E CE
The Journal of cell biology 20190808 9
Mutations in A-type nuclear lamins cause dilated cardiomyopathy, which is postulated to result from dysregulated gene expression due to changes in chromatin organization into active and inactive compartments. To test this, we performed genome-wide chromosome conformation analyses in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with a haploinsufficient mutation for lamin A/C. Compared with gene-corrected cells, mutant hiPSC-CMs have marked electrophysiological and contra ...[more]