Ontology highlight
ABSTRACT:
SUBMITTER: Strothman C
PROVIDER: S-EPMC6719460 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Strothman Claire C Farmer Veronica V Arpağ Göker G Rodgers Nicole N Podolski Marija M Norris Stephen S Ohi Ryoma R Zanic Marija M
The Journal of cell biology 20190816 9
Dynamic organization of microtubule minus ends is vital for the formation and maintenance of acentrosomal microtubule arrays. In vitro, both microtubule ends switch between phases of assembly and disassembly, a behavior called dynamic instability. Although minus ends grow slower, their lifetimes are similar to those of plus ends. The mechanisms underlying these distinct dynamics remain unknown. Here, we use an in vitro reconstitution approach to investigate minus-end dynamics. We find that minus ...[more]