Distinct Phenotypic and Genomic Signatures Underlie Contrasting Pathogenic Potential of <i>Staphylococcus epidermidis</i> Clonal Lineages.

ABSTRACT: Background: Staphylococcus epidermidis is a common skin commensal that has emerged as a pathogen in hospitals, mainly related to medical devices-associated infections. Noteworthy, infection rates by S. epidermidis have the tendency to rise steeply in next decades together with medical devices use and immunocompromized population growth. Staphylococcus epidermidis population structure includes two major clonal lineages (A/C and B) that present contrasting pathogenic potentials. To address this distinction and explore the basis of increased pathogenicity of A/C lineage, we performed a detailed comparative analysis using phylogenetic and integrated pangenome-wide-association study (panGWAS) approaches and compared the lineages's phenotypes in in vitro condit

SUBMITTER: Espadinha D 

PROVIDER: S-EPMC6719527 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature