Ontology highlight
ABSTRACT:
SUBMITTER: Marnef A
PROVIDER: S-EPMC6719620 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Marnef Aline A Finoux Anne-Laure AL Arnould Coline C Guillou Emmanuelle E Daburon Virginie V Rocher Vincent V Mangeat Thomas T Mangeot Philippe E PE Ricci Emiliano P EP Legube Gaëlle G
Genes & development 20190808 17-18
The ribosomal DNA (rDNA) represents a particularly unstable locus undergoing frequent breakage. DNA double-strand breaks (DSBs) within rDNA induce both rDNA transcriptional repression and nucleolar segregation, but the link between the two events remains unclear. Here we found that DSBs induced on rDNA trigger transcriptional repression in a cohesin- and HUSH (human silencing hub) complex-dependent manner throughout the cell cycle. In S/G2 cells, transcriptional repression is further followed by ...[more]