Ontology highlight
ABSTRACT:
SUBMITTER: Mathsyaraja H
PROVIDER: S-EPMC6719623 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Mathsyaraja Haritha H Freie Brian B Cheng Pei-Feng PF Babaeva Ekaterina E Catchpole Jonathen T JT Janssens Derek D Henikoff Steven S Eisenman Robert N RN
Genes & development 20190808 17-18
Although MAX is regarded as an obligate dimerization partner for MYC, its function in normal development and neoplasia is poorly defined. We show that B-cell-specific deletion of <i>Max</i> has a modest effect on B-cell development but completely abrogates Eµ-<i>Myc-</i>driven lymphomagenesis. While <i>Max</i> loss affects only a few hundred genes in normal B cells, it leads to the global down-regulation of <i>Myc</i>-activated genes in premalignant Eµ-<i>Myc</i> cells. We show that the balance ...[more]