Ontology highlight
ABSTRACT:
SUBMITTER: Ghurye J
PROVIDER: S-EPMC6719893 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Ghurye Jay J Rhie Arang A Walenz Brian P BP Schmitt Anthony A Selvaraj Siddarth S Pop Mihai M Phillippy Adam M AM Koren Sergey S
PLoS computational biology 20190821 8
Long-read sequencing and novel long-range assays have revolutionized de novo genome assembly by automating the reconstruction of reference-quality genomes. In particular, Hi-C sequencing is becoming an economical method for generating chromosome-scale scaffolds. Despite its increasing popularity, there are limited open-source tools available. Errors, particularly inversions and fusions across chromosomes, remain higher than alternate scaffolding technologies. We present a novel open-source Hi-C ...[more]