Synthesis of Ultrastable Gold Nanoparticles as a New Drug Delivery System.

ABSTRACT: Nanotechnologies are increasingly being developed for medical purposes. However, these nanomaterials require ultrastability for better control of their pharmacokinetics. The present study describes three types of ultrastable gold nanoparticles stabilized by thiolated polyethylene glycol groups remaining intact when subjected to some of the harshest conditions described thus far in the literature, such as autoclave sterilization, heat and freeze-drying cycles, salts exposure, and ultracentrifugation. Their stability is characterized by transmission electron microscopy, UV-visible spectroscopy, and dynamic light scattering. For comparison purposes, two conventional nanoparticle types were used to assess their colloidal stability under all conditions. The ability of ultrastable gold nanoparti

SUBMITTER: Masse F 

PROVIDER: S-EPMC6720288 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature