Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population.

ABSTRACT: BACKGROUND:Single nucleotide polymorphisms (SNPs) in several CYP genes have been associated with altered breast cancer (BC) risk in different populations. Despite this, there is a dearth of information on the roles of these SNPs in Jordanian BC patients. Therefore, this study aims to determine if there is any single nucleotide polymorphism (SNP) within CYP19A1, CYP2C19, CYP2C9, CYP1B1, CYP3A4, and CYP1A2 genes associated with BC in the Jordanian population. In addition, this work investigates the association between selected BC prognostic factors and variants of the aforementioned CYP candidate genes. METHODS:Blood samples were withdrawn from 221?BC patients and 218 healthy volunteers recruited from the Jordanian population. Genomic DNA was withdrawn and, after quantification and quality control, was genotyped using the Sequenom MassARRAY® system (iPLEX GOLD). Statistical analysis was then carried out to assess allelic and genotypic frequencies as well as genetic association between cases and controls. RESULTS:The CYP19A1 SNP rs7176005 (p?

SUBMITTER: Al-Eitan LN 

PROVIDER: S-EPMC6720417 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature