Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC6720459 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Li Mengqi M Zhang Chen-Song CS Zong Yue Y Feng Jin-Wei JW Ma Teng T Hu Meiqin M Lin Zhizhong Z Li Xiaotong X Xie Changchuan C Wu Yaying Y Jiang Dong D Li Ying Y Zhang Cixiong C Tian Xiao X Wang Wen W Yang Yanyan Y Chen Jie J Cui Jiwen J Wu Yu-Qing YQ Chen Xin X Liu Qing-Feng QF Wu Jianfeng J Lin Shu-Yong SY Ye Zhiyun Z Liu Ying Y Piao Hai-Long HL Yu Li L Zhou Zhuan Z Xie Xiao-Song XS Hardie D Grahame DG Lin Sheng-Cai SC
Cell metabolism 20190613 3
Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear. Here, we show that FBP-unoccupied aldolase interacts with and inhibits endoplasmic reticulum (ER)-localized transient receptor potential channel subfamily V, inhibiting calcium release in low glucose. The decrease of calcium at contact sites between ER and lysosome render ...[more]