Ontology highlight
ABSTRACT:
SUBMITTER: Ramirez D
PROVIDER: S-EPMC6720600 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Ramírez David D Concha Guierdy G Arévalo Bárbara B Prent-Peñaloza Luis L Zúñiga Leandro L Kiper Aytug K AK Rinné Susanne S Reyes-Parada Miguel M Decher Niels N Decher Niels N González Wendy W Caballero Julio J
International journal of molecular sciences 20190817 16
TASK-3 is a two-pore domain potassium (K<sub>2P</sub>) channel highly expressed in the hippocampus, cerebellum, and cortex. TASK-3 has been identified as an oncogenic potassium channel and it is overexpressed in different cancer types. For this reason, the development of new TASK-3 blockers could influence the pharmacological treatment of cancer and several neurological conditions. In the present work, we searched for novel TASK-3 blockers by using a virtual screening protocol that includes phar ...[more]