Ontology highlight
ABSTRACT:
SUBMITTER: Cui H
PROVIDER: S-EPMC6720627 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Cui Herong H Guo Wenbo W Zhang Beibei B Li Guoping G Li Tong T Yuan Yanyan Y Zhang Na N Yang Yuwei Y Feng Wuwen W Chu Fuhao F Wang Shenglan S Xu Bing B Wang Penglong P Lei Haimin H
International journal of molecular sciences 20190820 16
There is a need for an efficient and low-cost leading compound discovery mode. However, drug development remains slow, expensive, and risky. Here, this manuscript proposes a leading compound discovery strategy based on a combination of traditional Chinese medicine (TCM) formulae and pharmacochemistry, using a ligustrazine-betulinic acid derivative (BA-12) in the treatment of angiogenesis as an example. Blocking angiogenesis to inhibit the growth and metastasis of solid tumors is currently one re ...[more]