Ontology highlight
ABSTRACT:
SUBMITTER: Wiersma VR
PROVIDER: S-EPMC6721145 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Wiersma Valerie R VR Clarke Alex A Pouwels Simon D SD Perry Elizabeth E Abdullah Trefa M TM Kelly Clive C Soyza Anthony De A Hutchinson David D Eggleton Paul P Bremer Edwin E Bremer Edwin E
International journal of molecular sciences 20190819 16
The aetiology of rheumatoid arthritis (RA) is unknown, but citrullination of proteins is thought to be an initiating event. In addition, it is increasingly evident that the lung can be a potential site for the generation of autoimmune triggers before the development of joint disease. Here, we identified that serum levels of galectin-9 (Gal-9), a pleiotropic immunomodulatory protein, are elevated in RA patients, and are even further increased in patients with comorbid bronchiectasis, a lung disea ...[more]