Ontology highlight
ABSTRACT:
SUBMITTER: Solinas C
PROVIDER: S-EPMC6721578 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Solinas Cinzia C Migliori Edoardo E De Silva Pushpamali P Willard-Gallo Karen K
Cancers 20190820 8
The programmed cell death 1 (PD-1) pathway is an important regulator of immune responses in peripheral tissues, including abnormal situations such as the tumor microenvironment. This pathway is currently the principal target for immunotherapeutic compounds designed to block immune checkpoint pathways, with these drugs improving clinical outcomes in a number of solid and hematological tumors. Medical oncology is experiencing an immune revolution that has scientists and clinicians looking at alter ...[more]