Ontology highlight
ABSTRACT:
SUBMITTER: Carija A
PROVIDER: S-EPMC6721704 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Carija Anita A Pinheiro Francisca F Iglesias Valentin V Ventura Salvador S
Cells 20190808 8
The aggregation of proteins compromises cell fitness, either because it titrates functional proteins into non-productive inclusions or because it results in the formation of toxic assemblies. Accordingly, computational proteome-wide analyses suggest that prevention of aggregation upon misfolding plays a key role in sequence evolution. Most proteins spend their lifetimes in a folded state; therefore, it is conceivable that, in addition to sequences, protein structures would have also evolved to m ...[more]