The Autophagy-Cilia Axis: An Intricate Relationship.
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ABSTRACT:
SUBMITTER: Morleo M
PROVIDER: S-EPMC6721705 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
The Autophagy-Cilia Axis: An Intricate Relationship.
Morleo Manuela M Franco Brunella B
Cells 20190815 8
Primary cilia are microtubule-based organelles protruding from the surface of almost all vertebrate cells. This organelle represents the cell's antenna which acts as a communication hub to transfer extracellular signals into intracellular responses during development and in tissue homeostasis. Recently, it has been shown that loss of cilia negatively regulates autophagy, the main catabolic route of the cell, probably utilizing the autophagic machinery localized at the peri-ciliary compartment. O ...[more]
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