Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases.
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ABSTRACT:
SUBMITTER: Puttemans J
PROVIDER: S-EPMC6723032 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
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Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases.
Puttemans Janik J Lahoutte Tony T D'Huyvetter Matthias M Devoogdt Nick N
Pharmaceutics 20190801 8
Brain tumors are notoriously difficult to treat. The blood-brain barrier provides a sanctuary site where residual and metastatic cancer cells can evade most therapeutic modalities. The delicate nature of the brain further complicates the decision of eliminating as much tumorous tissue as possible while protecting healthy tissue. Despite recent advances in immunotherapy, radiotherapy and systemic treatments, prognosis of newly diagnosed patients remains dismal, and recurrence is still a universal ...[more]
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