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New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca²⁺-Modulating Activity Isolated from Sea Urchin Eggs.

ABSTRACT: Herein, we report on the synthesis of a small set of linear precursors of an inosine analogue of cyclic ADP-ribose (cADPR), a second messenger involved in Ca²⁺ mobilization from ryanodine receptor stores firstly isolated from sea urchin eggs extracts. The synthesized compounds were obtained starting from inosine and are characterized by an N1-alkyl chain replacing the "northern" ribose and a phosphate group attached at the end of the N1-alkyl chain and/or 5'-sugar positions. Preliminary Ca²⁺ mobilization assays, performed on differentiated C2C12 cells, are reported as well.

SUBMITTER: D'Errico S

PROVIDER: S-EPMC6723567 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca<sup>2+</sup>-Modulating Activity Isolated from Sea Urchin Eggs.

D'Errico Stefano S Basso Emy E Falanga Andrea Patrizia AP Marzano Maria M Pozzan Tullio T Piccialli Vincenzo V Piccialli Gennaro G Oliviero Giorgia G Borbone Nicola N

Marine drugs 20190817 8

Herein, we report on the synthesis of a small set of linear precursors of an inosine analogue of cyclic ADP-ribose (cADPR), a second messenger involved in Ca<sup>2+</sup> mobilization from ryanodine receptor stores firstly isolated from sea urchin eggs extracts. The synthesized compounds were obtained starting from inosine and are characterized by an N1-alkyl chain replacing the "northern" ribose and a phosphate group attached at the end of the N1-alkyl chain and/or 5'-sugar positions. Prelimina ...[more]

PMID: 31426471

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