Gangliosides: The Double-Edge Sword of Neuro-Ectodermal Derived Tumors.
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ABSTRACT:
SUBMITTER: Cavdarli S
PROVIDER: S-EPMC6723632 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
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Gangliosides: The Double-Edge Sword of Neuro-Ectodermal Derived Tumors.
Cavdarli Sumeyye S Groux-Degroote Sophie S Delannoy Philippe P
Biomolecules 20190727 8
Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are mostly localized at the plasma membrane in lipid raft domains and implicated in many cellular signaling pathways mostly by interacting with tyrosine kinase receptors. Gangliosides are divided into four series according to the number of sialic acid residues, which can be also modified by <i>O</i>-acetylation. Both ganglioside expression and sialic acid modifications can be modified in pathological conditions su ...[more]
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