Dataset Information

Toxicological Studies of Czech Beers and Their Constituents.

ABSTRACT:

Background

Czech beers are unique because they are brewed using specific technology at a particular latitude and for being entirely produced in the area of the Czech Republic. The purpose of this work is the evaluation of toxicological effects of a variety of freeze-dried Czech beers, their raw materials (malts, hops and yeast) and processed-beer (wort, hopped wort and young beer).

Methods

In vivo assays to evaluate the safety and protective effects in the Drosophila melanogaster eukaryotic system, and the in vitro evaluations of chemopreventive and DNA damage activity using the HL-60 tumour human cell line were carried out.

Results

The safe effects for all the analysed substances and general protective effects against H₂O₂ were shown both at the individual and genomic level in the Drosophila animal model, with some exceptions. Moreover, all the substances were able to inhibit the tumour cell growth and to induce DNA damage in the HL-60 cells at different levels (proapoptotic, single/double strands breaks and methylation status).

Conclusions

The promising effects shown by freeze-dried Czech beers due to their safety, protection against a toxin, chemopreventive potential and the induction of DNA damage in tumour cells, allow the proposition of Czech beer as a beverage with nutraceutic potential.

SUBMITTER: Merinas-Amo T

PROVIDER: S-EPMC6723778 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

Toxicological Studies of Czech Beers and Their Constituents.

Merinas-Amo Tania T Merinas-Amo Rocío R García-Zorrilla Victoria V Velasco-Ruiz Alejandro A Chladek Ladislav L Plachy Vladimir V Del Río-Celestino Mercedes M Font Rafael R Kokoska Ladislav L Alonso-Moraga Ángeles Á

Foods (Basel, Switzerland) 20190808 8

<h4>Background</h4>Czech beers are unique because they are brewed using specific technology at a particular latitude and for being entirely produced in the area of the Czech Republic. The purpose of this work is the evaluation of toxicological effects of a variety of freeze-dried Czech beers, their raw materials (malts, hops and yeast) and processed-beer (wort, hopped wort and young beer).<h4>Methods</h4>In vivo assays to evaluate the safety and protective effects in the <i>Drosophila melanogast ...[more]

PMID: 31398837

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Dataset Information

Toxicological Studies of Czech Beers and Their Constituents.

Background

Methods

Results

Conclusions

Publications

Toxicological Studies of Czech Beers and Their Constituents.

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