Ontology highlight
ABSTRACT:
SUBMITTER: Andrianov AM
PROVIDER: S-EPMC6723994 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Andrianov Alexander M AM Nikolaev Grigory I GI Kornoushenko Yuri V YV Xu Wei W Jiang Shibo S Tuzikov Alexander V AV
Viruses 20190813 8
Despite recent progress in the development of novel potent HIV-1 entry/fusion inhibitors, there are currently no licensed antiviral drugs based on inhibiting the critical interactions of the HIV-1 envelope gp120 protein with cellular receptor CD4. In this connection, studies on the design of new small-molecule compounds able to block the gp120-CD4 binding are still of great value. In this work, in silico design of drug-like compounds containing the moieties that make the ligand active towards gp ...[more]