Ontology highlight
ABSTRACT:
SUBMITTER: Halper-Stromberg E
PROVIDER: S-EPMC6724137 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Halper-Stromberg Eitan E Gillenwater Lucas L Cruickshank-Quinn Charmion C O'Neal Wanda Kay WK Reisdorph Nichole N Petrache Irina I Zhuang Yonghua Y Labaki Wassim W WW Curtis Jeffrey L JL Wells James J Rennard Stephen S Pratte Katherine A KA Woodruff Prescott P Stringer Kathleen A KA Kechris Katerina K Bowler Russell P RP
Metabolites 20190725 8
Smoking causes chronic obstructive pulmonary disease (COPD). Though recent studies identified a COPD metabolomic signature in blood, no large studies examine the metabolome in bronchoalveolar lavage (BAL) fluid, a more direct representation of lung cell metabolism. We performed untargeted liquid chromatography-mass spectrometry (LC-MS) on BAL and matched plasma from 115 subjects from the SPIROMICS cohort. Regression was performed with COPD phenotypes as the outcome and metabolites as the predict ...[more]