Ontology highlight
ABSTRACT:
SUBMITTER: Kumar D
PROVIDER: S-EPMC6724692 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Kumar Darshan D Golchoubian Banafsheh B Belevich Ilya I Jokitalo Eija E Schlaitz Anne-Lore AL
Molecular biology of the cell 20190417 12
The endoplasmic reticulum (ER) is extensively remodeled during metazoan open mitosis. However, whether the ER becomes more tubular or more cisternal during mitosis is controversial, and dedicated factors governing the morphology of the mitotic ER have remained elusive. Here, we describe the ER membrane proteins REEP3 and REEP4 as major determinants of ER morphology in metaphase cells. REEP3/4 are specifically required for generating the high-curvature morphology of mitotic ER and promote ER tubu ...[more]