Ontology highlight
ABSTRACT:
SUBMITTER: Chuang SC
PROVIDER: S-EPMC6725444 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Chuang Shih-Chieh SC Zhao Wangfa W Bauchwitz Robert R Yan Qijiang Q Bianchi Riccardo R Wong Robert K S RK
The Journal of neuroscience : the official journal of the Society for Neuroscience 20050801 35
Mutations in FMR1, which encodes the fragile X mental retardation protein (FMRP), are the cause of fragile X syndrome (FXS), an X-linked mental retardation disorder. Inactivation of the mouse gene Fmr1 confers a number of FXS-like phenotypes including an enhanced susceptibility to epileptogenesis during development. We find that in a FXS mouse model, in which the function of FMRP is suppressed, synaptically released glutamate induced prolonged epileptiform discharges resulting from enhanced grou ...[more]