Ontology highlight
ABSTRACT:
SUBMITTER: Carro E
PROVIDER: S-EPMC6725866 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Carro Eva E Spuch Carlos C Trejo Jose Luis JL Antequera Desiré D Torres-Aleman Ignacio I
The Journal of neuroscience : the official journal of the Society for Neuroscience 20051101 47
The involvement of circulating insulin-like growth factor I (IGF-I) in the beneficial effects of physical exercise on the brain makes this abundant serum growth factor a physiologically relevant neuroprotective signal. However, the mechanisms underlying neuroprotection by serum IGF-I remain primarily unknown. Among many other neuroprotective actions, IGF-I enhances clearance of brain amyloid beta (Abeta) by modulating transport/production of Abeta carriers at the blood-brain interface in the cho ...[more]