Ontology highlight
ABSTRACT:
SUBMITTER: Calo L
PROVIDER: S-EPMC6726088 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Calò L L Bruno V V Spinsanti P P Molinari G G Korkhov V V Esposito Z Z Patanè M M Melchiorri D D Freissmuth M M Nicoletti F F Nicoletti F F
The Journal of neuroscience : the official journal of the Society for Neuroscience 20050301 9
We examined the interaction between ephrins and metabotropic glutamate (mGlu) receptors in the developing brain and cultured neurons. EphrinB2 coimmunoprecipitated with mGlu1a receptors, in all of the brain regions examined, and with mGlu5 receptors in the corpus striatum. In striatal slices, activation of ephrinB2 by a clustered form of its target receptor, EphB1, amplified the mGlu receptor-mediated stimulation of polyphosphoinositide (PI) hydrolysis. This effect was abolished in slices treate ...[more]