Ontology highlight
ABSTRACT:
SUBMITTER: Zhu X
PROVIDER: S-EPMC6726629 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Zhu Xinzhou X Yan Jingyi J Bregere Catherine C Zelmer Andrea A Goerne Tessa T Kapfhammer Josef P JP Guzman Raphael R Wellmann Sven S
Nature communications 20190904 1
Hypoxic ischemia (HI) is an acute brain threat across all age groups. Therapeutic hypothermia ameliorates resulting injury in neonates but its side effects prevent routine use in adults. Hypothermia up-regulates a small protein subset that includes RNA-binding motif protein 3 (RBM3), which is neuroprotective under stressful conditions. Here we show how RBM3 stimulates neuronal differentiation and inhibits HI-induced apoptosis in the two areas of persistent adult neurogenesis, the subventricular ...[more]