Dataset Information

Physicochemical data of p-cresol, butyric acid, and ammonia.

ABSTRACT: There is a renewed interest in treating odorous contaminants such as butyric acid, p-cresol, and ammonia that are emitted from animal farming operations. However, developing newer treatment technologies require quantitative information regarding the properties of the target pollutants. Therefore, in this communication, baseline data related to physicochemical and thermodynamic properties of butyric acid, p-cresol, and ammonia were predicted using computational chemistry. Density functional theory was employed via B3LYP functional coupled with polarized 6-31G (d) basis set without any solvent effects using Gaussian 16W and GaussView6. The predicted baseline properties collected here are expected to be useful to scientists and engineers working in environmental mitigation technologies in developing treatment processes and make the animal agricultural industry environmental friendly and sustainable.

SUBMITTER: Kolar P

PROVIDER: S-EPMC6727009 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Similar Datasets

Project description:Benzodiazepines are used for treating anxiety, epilepsy, muscle spasm, alcohol withdrawal, palliation, insomnia, and sedation as they allosterically modulate ?-amino-butyric acid type A (GABAA) receptors. Despite widespread use, the importance and mechanism of their immune side-effects are poorly understood. Herein we sought to elucidate the impact and mechanism of benzodiazepine-induced susceptibility to infection at anxiolytic doses in mice.Animal randomized controlled trial.Laboratory.Adult female C57BL/6 and BALB/c mice.The effect of a subsedative, anxiolytic dose of diazepam (2 mg kg intraperitoneal) was investigated in a murine Streptococcus pneumoniae pneumonia model.Mortality, bacterial and cytokine load, cell recruitment, and intracellular pH were measured. Diazepam treatment did not affect immune homeostasis in the lung. However, diazepam increased mortality and bacterial load from S. pneumoniae pneumonia. The increases in mortality and bacterial load were reversed by a GABAA antagonist, bicuculline, indicating dependence on GABAA receptor signaling. While cell recruitment was unaltered by diazepam, the cytokine response to infection was affected, suggesting that local responses to the pathogen were perturbed. Macrophage and monocytes expressed benzodiazepine sensitive (?1-?2) GABAA receptors. Interestingly macrophage GABAA receptor expression was regulated by bacterial toll-like receptor agonists and cytokines indicating an endogenous role in the immune response. Functionally diazepam appeared to counteract the endogenous down-regulation of GABAA signaling during infection. Consistent with augmented GABAA signaling, diazepam provoked intracellular acidosis in macrophage, leading to impaired cytokine production, bacterial phagocytosis and killing. In contrast, selective benzodiazepines that do not target the ?1 GABAA subunit did not affect macrophage function ex vivo or increase susceptibility to pneumonia in vivo.Our data highlight the regulation of macrophage function by GABAA receptor signaling and the potential harm of benzodiazepine exposure during pneumonia. Therapeutically, selective drugs may improve the safety profile of benzodiazepines.

Dataset Information

Physicochemical data of p-cresol, butyric acid, and ammonia.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets