Ex vivo electrochemical measurement of glutamate release during spinal cord injury.
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ABSTRACT:
SUBMITTER: Nolan JK
PROVIDER: S-EPMC6727010 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Ex vivo electrochemical measurement of glutamate release during spinal cord injury.
Nolan James K JK Nguyen Tran N H TNH Fattah Mara M Page Jessica C JC Shi Riyi R Lee Hyowon H
MethodsX 20190823
Excessive glutamate release following traumatic spinal cord injury (SCI) has been associated with exacerbating the extent of SCI. However, the mechanism behind sustained high levels of extracellular glutamate is unclear. Spinal cord segments mounted in a sucrose double gap recording chamber are an established model for traumatic spinal cord injury. We have developed a method to record, with micro-scale printed glutamate biosensors, glutamate release from <i>ex vivo</i> rat spinal cord segments f ...[more]
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