Ontology highlight
ABSTRACT:
SUBMITTER: Wang T
PROVIDER: S-EPMC6727026 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Wang Tao T Xu Ya-Qiong YQ Yuan Ye-Xian YX Xu Ping-Wen PW Zhang Cha C Li Fan F Wang Li-Na LN Yin Cong C Zhang Lin L Cai Xing-Cai XC Zhu Can-Jun CJ Xu Jing-Ren JR Liang Bing-Qing BQ Schaul Sarah S Xie Pei-Pei PP Yue Dong D Liao Zheng-Rui ZR Yu Lu-Lu LL Luo Lv L Zhou Gan G Yang Jin-Ping JP He Zhi-Hui ZH Du Man M Zhou Yu-Ping YP Deng Bai-Chuan BC Wang Song-Bo SB Gao Ping P Zhu Xiao-Tong XT Xi Qian-Yun QY Zhang Yong-Liang YL Shu Gang G Jiang Qing-Yan QY
EMBO reports 20190718 9
The conversion of skeletal muscle fiber from fast twitch to slow-twitch is important for sustained and tonic contractile events, maintenance of energy homeostasis, and the alleviation of fatigue. Skeletal muscle remodeling is effectively induced by endurance or aerobic exercise, which also generates several tricarboxylic acid (TCA) cycle intermediates, including succinate. However, whether succinate regulates muscle fiber-type transitions remains unclear. Here, we found that dietary succinate su ...[more]