An EV-Associated Gene Signature Correlates with Hypoxic Microenvironment and Predicts Recurrence in Lung Adenocarcinoma.
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ABSTRACT:
SUBMITTER: Cao B
PROVIDER: S-EPMC6727147 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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An EV-Associated Gene Signature Correlates with Hypoxic Microenvironment and Predicts Recurrence in Lung Adenocarcinoma.
Cao Bangrong B Dai Wei W Ma Shiqi S Wang Qifeng Q Lan Mei M Luo Huaichao H Chen Tingqing T Yang Xiaojun X Zhu Guiquan G Li Qiang Q Lang Jinyi J
Molecular therapy. Nucleic acids 20190807
Extracellular vesicles (EVs) mediate intercellular communications in the tumor microenvironment and contribute to the aggressive phenomenon of cancers. Although EVs in body fluids are supposed to be ideal biomarkers for cancer diagnosis and prognosis, it remains difficult to distinguish the tumor-derived EVs from those released by other tissues. We hypothesized that analyzing the EV-related molecules in tumor tissues would help to estimate the prognostic value of tumor-specific EVs. Here, we inv ...[more]
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