Ontology highlight
ABSTRACT:
SUBMITTER: Terao C
PROVIDER: S-EPMC6727201 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Terao Chikashi C Raychaudhuri Soumya S Gregersen Peter K PK
Annual review of genomics and human genetics 20160523
Rheumatoid arthritis (RA) is the most common inflammatory arthritis and exhibits genetic overlap with other autoimmune and inflammatory disorders. Although predominant associations with the HLA-DRB1 locus have been known for decades, recent data have revealed additional insight into the likely causative variants within HLA-DRB1 as well as within other HLA loci that contribute to disease risk. In addition, more than 100 common variants in non-HLA loci have been implicated in disease susceptibilit ...[more]