Influence of low-dose radiation on abscopal responses in patients receiving high-dose radiation and immunotherapy.
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ABSTRACT:
SUBMITTER: Menon H
PROVIDER: S-EPMC6727581 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Influence of low-dose radiation on abscopal responses in patients receiving high-dose radiation and immunotherapy.
Menon Hari H Chen Dawei D Ramapriyan Rishab R Verma Vivek V Barsoumian Hampartsoum B HB Cushman Taylor R TR Younes Ahmed I AI Cortez Maria A MA Erasmus Jeremy J JJ de Groot Patricia P Carter Brett W BW Hong David S DS Glitza Isabella C IC Ferrarotto Renata R Altan Mehmet M Diab Adi A Chun Stephen G SG Heymach John V JV Tang Chad C Nguyen Quynh N QN Welsh James W JW
Journal for immunotherapy of cancer 20190904 1
<h4>Background</h4>Preclinical evidence suggests that low-dose radiation may overcome the inhibitory effects of the tumor stroma and improve a tumor's response to immunotherapy, when combined with high-dose radiation to another tumor. The aim of this study was to evaluate tumor responses to this combination in a clinical setting.<h4>Methods</h4>A post-hoc analysis of 3 ongoing immunoradiation trials was performed. Twenty-six (of 155) patients received low-dose radiation (1-20 Gy total), either a ...[more]
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