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Regioselective trans-Carboboration of Propargyl Alcohols.

ABSTRACT: Proper choice of the base allowed trans-diboration of propargyl alcohols with B2(pin)2 to evolve into an exquisitely regioselective procedure for net trans-carboboration. The method is modular as to the newly introduced carbon substituent (aryl, methyl, allyl, benzyl, alkynyl), which is invariably placed distal to the -OH group.

SUBMITTER: Jin H

PROVIDER: S-EPMC6727597 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Regioselective trans-Carboboration of Propargyl Alcohols.

Jin Hongming H Fürstner Alois A

Organic letters 20190417 9

Proper choice of the base allowed trans-diboration of propargyl alcohols with B<sub>2</sub>(pin)<sub>2</sub> to evolve into an exquisitely regioselective procedure for net trans-carboboration. The method is modular as to the newly introduced carbon substituent (aryl, methyl, allyl, benzyl, alkynyl), which is invariably placed distal to the -OH group. ...[more]

PMID: 30993987

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