Ontology highlight
ABSTRACT:
SUBMITTER: Chen RH
PROVIDER: S-EPMC6727638 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20190424 13
Mitosis in metazoans involves detachment of chromosomes from the nuclear envelope (NE) and NE breakdown, whereas yeasts maintain the nuclear structure throughout mitosis. It remains unknown how chromosome attachment to the NE might affect chromosome movement in yeast. By using a rapamycin-induced dimerization system to tether a specific locus of the chromosome to the NE, I found that the tethering delays the separation and causes missegregation of the region distal to the tethered site. The phen ...[more]