Ontology highlight
ABSTRACT:
SUBMITTER: Fu H
PROVIDER: S-EPMC6727982 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Fu Hualong H Tang Weiting W Chen Zhen Z Belov Vasily V VV Zhang Genwei G Shao Tuo T Zhang Xiaofei X Yu Qingzhen Q Rong Jian J Deng Xiaoyun X Han Wei W Myers Scott J SJ Giffenig Pilar P Wang Lu L Josephson Lee L Shao Yihan Y Davenport April T AT Daunais James B JB Papisov Mikhail M Yuan Hongjie H Li Zijing Z Traynelis Stephen F SF Liang Steven H SH
ACS chemical neuroscience 20190227 5
GluN2B is the most studied subunit of N-methyl-d-aspartate receptors (NMDARs) and implicated in the pathologies of various central nervous system disorders and neurodegenerative diseases. As pan NMDAR antagonists often produce debilitating side effects, new approaches in drug discovery have shifted to subtype-selective NMDAR modulators, especially GluN2B-selective antagonists. While positron emission tomography (PET) studies of GluN2B-selective NMDARs in the living brain would enable target enga ...[more]