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Parental predictors of HPV vaccine initiation among low-income Hispanic females aged 11-17?years.

ABSTRACT: PURPOSE:Hispanic women experience a disproportionate burden of cervical cancer morbidity and mortality compared to non-Hispanic women. Increasing HPV vaccination among Hispanic adolescents can help alleviate disparities. This study aimed to identify parental psychosocial predictors associated with HPV vaccine initiation and correlates of parental intentions to obtain the vaccine for their Hispanic adolescent daughters aged 11-17?years. METHODS:This study is part of a larger three-arm randomized controlled trial testing the effectiveness of interventions to increase HPV vaccination. Parents of adolescent females were recruited in community clinics where we conducted baseline surveys. We obtained electronic medical records six months after baseline to assess vaccination status. Multilevel logistic regression was used to identify correlates of parental intentions to vaccinate and predictors of HPV vaccine initiation. Analyses with initiation as the outcome also controlled for intervention study arm. The Integrated Behavioral Model guided selection of psychosocial and outcome variables. RESULTS:Our sample (n?=?765) consisted mostly of mothers with less than a high school education born outside of the U.S. Forty-one percent had a household income less than $15,000. Most daughters had public or private insurance. Twenty-one percent initiated the HPV vaccine series. Correlates of intention to vaccinate intention included subjective norms related to daughter's doctor (AOR?=?1.04; 95% CI 1.01-1.07), belief that the vaccine is safe (AOR?=?1.38; 95% CI 1.06-1.78), self-efficacy to obtain the vaccine for their daughter (AOR?=?2.39; 95% CI 1.52-3.77), and parental concern about vaccine side effects (AOR?=?0.73; 95% CI 0.60-0.89). Intentions predicted initiation (AOR?=?2.01; 95% CI 1.10-5.26); concern about sexual disinhibition decreased the odds of having a vaccinated daughter at follow-up (AOR?=?0.66; 95% CI 0.47-0.92). DISCUSSION:Parental intention and concerns about sexual disinhibition predict vaccine initiation. Further research is needed to explore the role of intention as a potential mediator between psychosocial variables and vaccination status.

SUBMITTER: Rodriguez SA

PROVIDER: S-EPMC6728080 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Parental predictors of HPV vaccine initiation among low-income Hispanic females aged 11-17 years.

Rodriguez Serena A SA Savas Lara S LS Baumler Elizabeth E Nyitray Alan G AG Mullen Patricia Dolan PD Vernon Sally W SW Fernandez Maria E ME

Vaccine 20180703 33

<h4>Purpose</h4>Hispanic women experience a disproportionate burden of cervical cancer morbidity and mortality compared to non-Hispanic women. Increasing HPV vaccination among Hispanic adolescents can help alleviate disparities. This study aimed to identify parental psychosocial predictors associated with HPV vaccine initiation and correlates of parental intentions to obtain the vaccine for their Hispanic adolescent daughters aged 11-17 years.<h4>Methods</h4>This study is part of a larger three- ...[more]

PMID: 29980388

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Project description:BACKGROUND:HPV vaccination with the bivalent vaccine is efficacious against HPV16 and 18 infections and cross-protection against non-vaccine HPV types has been demonstrated. Here, we assessed (cross-) protective effects of the bivalent HPV16/18 vaccine on incident and persistent infections and viral load (VL) of fifteen HPV types in an observational cohort study monitoring HPV vaccine effects. METHODS:Vaginal samples were obtained annually. Type-specific VL assays were developed for HPV6,11,31 33,35,39,45,51,52,56,58,59 and 66 and used in addition to existing HPV16 and 18 assays. Rate differences of incident clearing and persistent infections were correlated with differences in VL and vaccination status. RESULTS:HPV16/18 vaccination resulted in significantly lower incidence of HPV16/18 infections and significantly lower VL in breakthrough HPV16 (p<0.01) and 18 infections (p<0.01). The effects of vaccination on non-vaccine type VL were ambiguous. Incidence and/or persistence rates of HPV31, 33, 35 and 45 were reduced in the vaccinated group. However, no significant type specific VL effects were found against HPV31, 33, 45, 52 in the vaccinated group. For HPV 6, 59 and 66 no significant reductions in numbers of incident and persistent infections were found, however borderline) VL reductions following vaccination were observed for HPV6 (p = 0.01), 59 (p = 0.10) and 66 (p = 0.03), suggesting a minor effect of the vaccine on the VL level of these HPV types. Overall, vaccination resulted in infections with slightly lower VL, irrespective of HPV type. CONCLUSIONS:In conclusion, vaccination with the bivalent HPV16/18 vaccine results in significantly reduced numbers of HPV16 and 18 incidence rates and reduced VL in breakthrough infections. Significant reductions in incident and/or persistent HPV31, 33, 35 and 45 infections were found, but no significant effect was observed on the VL for infections with these types. For the other non-vaccine HPV types no reduction in incident and/or persistent infections were found, but overall the VL tended to be somewhat lower in vaccinated women.

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Parental predictors of HPV vaccine initiation among low-income Hispanic females aged 11-17?years.

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Parental predictors of HPV vaccine initiation among low-income Hispanic females aged 11-17 years.

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Parental predictors of HPV vaccine initiation among low-income Hispanic females aged 11-17?years.

Publications

Parental predictors of HPV vaccine initiation among low-income Hispanic females aged 11-17 years.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

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Parental predictors of HPV vaccine initiation among low-income Hispanic females aged 11-17 years.