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Food intake of folate, folic acid and other B vitamins with lung cancer risk in a low-income population in the Southeastern United States.


ABSTRACT: PURPOSE:We prospectively examined associations of lung cancer risk with food intake of B vitamins involved in one-carbon metabolism and the use of folic acid-containing supplements among a low-income population of black and white adults in the Southeastern US. METHODS:Within the Southern Community Cohort Study, we included 1064 incident lung cancer cases among 68,236 participants aged 40-79 years at study enrollment. Food intake and the use of folic acid-containing supplements were assessed using a validated food frequency questionnaire at study enrollment. Multivariate Cox regression was used to estimate hazards ratios (HRs) and the 95% confidence intervals (CIs). RESULTS:Folate and/or folic acid intake from food were not associated with lung cancer risk; HRs (95% CI) for highest compared with lowest quartile were 1.08 (0.91-1.29) for total dietary folate, 1.00 (0.84-1.19) for food folate, and 1.09 (0.91-1.30) for food folic acid, respectively. Similarly, no associations were observed after stratifying by sex, race and smoking status, except for a positive association with total dietary folate intake among black women (HR 1.46, 95% CI 1.04-2.05 for the highest quartile compared with the lowest quartile, P trend?=?0.02). Neither the use of folic acid-containing supplements nor food intake of vitamin B6, vitamin B12 and riboflavin were associated with lung cancer risk. CONCLUSIONS:Our findings do not support a protective effect of folate or folic acid for lung cancer prevention in a low-income population of black and white adults in the Southeastern US. Our finding of a positive association with total dietary folate intake among black women needs to be interpreted with caution and replicated in other studies.

SUBMITTER: Takata Y 

PROVIDER: S-EPMC6728240 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Food intake of folate, folic acid and other B vitamins with lung cancer risk in a low-income population in the Southeastern United States.

Takata Yumie Y   Shu Xiao-Ou XO   Buchowski Maciej S MS   Munro Heather M HM   Wen Wanqing W   Steinwandel Mark D MD   Hargreaves Margaret K MK   Blot William J WJ   Cai Qiuyin Q  

European journal of nutrition 20190305 2


<h4>Purpose</h4>We prospectively examined associations of lung cancer risk with food intake of B vitamins involved in one-carbon metabolism and the use of folic acid-containing supplements among a low-income population of black and white adults in the Southeastern US.<h4>Methods</h4>Within the Southern Community Cohort Study, we included 1064 incident lung cancer cases among 68,236 participants aged 40-79 years at study enrollment. Food intake and the use of folic acid-containing supplements wer  ...[more]

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