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Amyloid-? Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena.


ABSTRACT: A disintegrin and metalloproteinase 10 (ADAM10) is a synaptic enzyme that has been previously shown to limit amyloid-?1-42 (A?1-42) peptide formation in Alzheimer's disease (AD). Furthermore, ADAM10 participates to spine shaping through the cleavage of adhesion molecules and its activity is under the control of synaptic plasticity events. In particular, long-term depression (LTD) promotes ADAM10 synaptic localization triggering its forward trafficking to the synapse, while long-term potentiation elicits ADAM10 internalization. Here, we show that a short-term in vitro exposure to A?1-42 oligomers, at a concentration capable of inducing synaptic depression and spine loss, triggers an increase in ADAM10 synaptic localization in hippocampal neuronal cultures. However, the A?1-42 oligomers-induced synaptic depression does not foster ADAM10 delivery to the synapse, as the physiological LTD, but impairs ADAM10 endocytosis. Moreover, A?1-42 oligomers-induced inhibition of ADAM10 internalization requires neuronal activity and the activation of the NMDA receptors. These data suggest that, at the synaptic level, A?1-42 oligomers trigger an aberrant plasticity mechanism according to which A?1-42 oligomers can downregulate A? generation through the modulation of ADAM10 synaptic availability. Moreover, the increased activity of ADAM10 towards its synaptic substrates could also affect the structural plasticity phenomena. Overall, these data shed new lights on the strict and complex relationship existing between synaptic activity and the primary mechanisms of AD pathogenesis.

SUBMITTER: Marcello E 

PROVIDER: S-EPMC6728288 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena.

Marcello Elena E   Musardo Stefano S   Vandermeulen Lina L   Pelucchi Silvia S   Gardoni Fabrizio F   Santo Nadia N   Antonucci Flavia F   Di Luca Monica M  

Molecular neurobiology 20190413 10


A disintegrin and metalloproteinase 10 (ADAM10) is a synaptic enzyme that has been previously shown to limit amyloid-β<sub>1-42</sub> (Aβ<sub>1-42</sub>) peptide formation in Alzheimer's disease (AD). Furthermore, ADAM10 participates to spine shaping through the cleavage of adhesion molecules and its activity is under the control of synaptic plasticity events. In particular, long-term depression (LTD) promotes ADAM10 synaptic localization triggering its forward trafficking to the synapse, while  ...[more]

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