Ontology highlight
ABSTRACT:
SUBMITTER: Komura S
PROVIDER: S-EPMC6728361 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190905 1
Clear cell sarcoma (CCS) is a rare soft tissue sarcoma caused by the EWS/ATF1 fusion gene. Here, we established induced pluripotent stem cells (iPSCs) from EWS/ATF1-controllable murine CCS cells harboring sarcoma-associated genetic abnormalities. Sarcoma-iPSC mice develop secondary sarcomas immediately after EWS/ATF1 induction, but only in soft tissue. EWS/ATF1 expression induces oncogene-induced senescence in most cell types in sarcoma-iPSC mice but prevents it in sarcoma cells. We identify Tpp ...[more]