Ontology highlight
ABSTRACT:
SUBMITTER: Jin L
PROVIDER: S-EPMC6728370 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190905 1
Chimeric antigen receptor (CAR) T-cell therapy targeting solid tumors has stagnated as a result of tumor heterogeneity, immunosuppressive microenvironments, and inadequate intratumoral T cell trafficking and persistence. Early (≤3 days) intratumoral presentation of CAR T cells post-treatment is a superior predictor of survival than peripheral persistence. Therefore, we have co-opted IL-8 release from tumors to enhance intratumoral T-cell trafficking through a CAR design for maximal antitumor act ...[more]