Sexual trauma history is associated with reduced orbitofrontal network strength in substance-dependent women.

ABSTRACT:

Aim

Substance use disorders (SUDs) are highly comorbid with post-traumatic stress disorder (PTSD). PTSD-SUD comorbidity is associated with greater functional impairments and relapse risk. Women with SUDs experience markedly higher rates of trauma and PTSD compared to men with SUDs, particularly due to sexual and domestic abuse. Despite the strong association between trauma exposure and SUDs, the neurobiological correlates are understudied, particularly among females with SUDs. However, there is indication of abnormal somatic and interoceptive processing in women with PTSD. The present study examines interoception-linked differences in intrinsic brain networks in a group of women with SUDs and varying histories of trauma exposure, some of whom have a current PTSD diagnosis.

Metho

SUBMITTER: Poppa T 

PROVIDER: S-EPMC6728879 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature