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Tools for Understanding Nanoscale Lipid Regulation of Ion Channels.

ABSTRACT: Anionic phospholipids are minor but prominent components of the plasma membrane that are necessary for ion channel function. Their persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP2), initially suggested they act as channel cofactors. However, recent technologies have established an emerging system of nanoscale signaling to ion channels based on lipid compartmentalization (clustering), direct lipid binding, and local lipid dynamics that allow cells to harness lipid heterogeneity to gate ion channels. The new tools to study lipid binding are set to transform our view of the membrane and answer important questions surrounding ion channel-delimited processes such as mechanosensation.

SUBMITTER: Robinson CV

PROVIDER: S-EPMC6729126 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Tools for Understanding Nanoscale Lipid Regulation of Ion Channels.

Robinson Carol V CV Rohacs Tibor T Hansen Scott B SB

Trends in biochemical sciences 20190503 9

Anionic phospholipids are minor but prominent components of the plasma membrane that are necessary for ion channel function. Their persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP<sub>2</sub>), initially suggested they act as channel cofactors. However, recent technologies have established an emerging system of nanoscale signaling to ion channels based on lipid compartmentalization (clustering), direct lipid binding, and local lipid dynamics that allow cell ...[more]

PMID: 31060927

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