Ontology highlight
ABSTRACT:
SUBMITTER: Yin X
PROVIDER: S-EPMC6729343 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Yin Xinghua X Kidd Grahame J GJ Pioro Erik P EP McDonough Jennifer J Dutta Ranjan R Feltri M Laura ML Wrabetz Lawrence L Messing Albee A Wyatt Ryan M RM Balice-Gordon Rita J RJ Trapp Bruce D BD
The Journal of neuroscience : the official journal of the Society for Neuroscience 20040401 15
Axonal degeneration is the major cause of permanent neurological disability in individuals with inherited diseases of myelin. Axonal and neuronal changes that precede axonal degeneration, however, are not well characterized. We show here that dysmyelinated lower motor neurons retract and regenerate dysfunctional presynaptic terminals, leading to severe neurological disability before axonal degeneration. In addition, dysmyelination led to a decreased synaptic quantal content, an indicator of syna ...[more]